How to pronounce "possession"

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So it was about four years ago, five years ago,

I was sitting on a stage in Philadelphia, I think it was,

with a bag similar to this.

And I was pulling a molecule out of this bag.

And I was saying, you don't know this molecule really well,

but your body knows it extremely well.

And I was thinking that your body hated it, at the time,

because we are very immune to this. This is called alpha-gal epitope.

And the fact that pig heart valves have lots of these on them

is the reason that you can't transplant a pig heart valve into a person easily.

Actually our body doesn't hate these.

Our body loves these. It eats them.

I mean, the cells in our immune system are always hungry.

And if an antibody is stuck to one of these things

on the cell, it means "that's food."

Now, I was thinking about that and I said, you know, we've got this

immune response to this ridiculous molecule

that we don't make, and we see it a lot in other animals and stuff.

But I said we can't get rid of it,

because all the people who tried to transplant heart valves

found out you can't get rid of that immunity.

And I said, why don't you use that?

What if I could stick this molecule,

slap it onto a bacteria

that was pathogenic to me, that had just invaded my lungs?

I mean I could immediately tap into

an immune response that was already there,

where it was not going to take five or six days to develop it --

it was going to immediately attack whatever this thing was on.

It was kind of like the same thing that happens when you,

like when you're getting stopped for a traffic ticket in L.A.,

and the cop drops a bag of marijuana in the back of your car,

and then charges you for possession of marijuana.

It's like this very fast, very efficient way to get people off the street.

(Laughter)

So you can take a bacteria

that really doesn't make these things at all,

and if you could clamp these on it really well

you have it taken off the street.

And for certain bacteria

we don't have really efficient ways to do that anymore.

Our antibiotics are running out.

And, I mean, the world apparently is running out too.

So probably it doesn't matter 50 years from now --

streptococcus and stuff like that will be rampant --

because we won't be here. But if we are --

(Laughter)

we're going to need something to do with the bacteria.

So I started working with this thing,

with a bunch of collaborators.

And trying to attach this to things that were

themselves attached to certain specific target zones,

bacteria that we don't like.

And I feel now like George Bush.

It's like "mission accomplished."

So I might be doing something dumb, just like he was doing at the time.

But basically what I was talking about there we've now gotten to work.

And it's killing bacteria. It's eating them.

This thing can be stuck, like that little green triangle up there,

sort of symbolizing this right now.

You can stick this to something called a DNA aptamer.

And that DNA aptamer will attach specifically

to a target that you have selected for it.

So you can find a little feature on a bacterium that you don't like,

like Staphylococcus -- I don't like it in particular,

because it killed a professor friend of mine last year.

It doesn't respond to antibiotics. So I don't like it.

And I'm making an aptamer that will have this attached to it.

That will know how to find Staph when it's in your body,

and will alert your immune system to go after it.

Here's what happened. See that line on the very top

with the little dots?

That's a bunch of mice that had been poisoned

by our scientist friends down in Texas,

at Brooks Air Base, with anthrax.

And they had also been treated with a drug that we made

that would attack anthrax in particular,

and direct your immune system to it.

You'll notice they all lived, the ones on the top line --

that's a 100 percent survival rate.

And they actually lived another 14 days,

or 28 when we finally killed them,

and took them apart and figured out what went wrong.

Why did they not die?

And they didn't die because they didn't have anthrax anymore.

So we did it. Okay?

(Applause)

Mission accomplished!

(Applause)

Phonetic Breakdown of "possession"

Learn how to break down "possession" into its phonetic components. Understanding syllables and phonetics helps with pronunciation, spelling, and language learning.

pos-ses-sion

3 syllables

Standard Phonetic Pronunciation:

/pəˈzɛʃən/

Phonetic representation based on standard dictionaries

IPA Phonetic Pronunciation:

P AH0 Z EH1 SH AH0 N

Standard phonetic transcription to help with precise pronunciation

Pronunciation Tips:

Stress the first syllable
Pay attention to vowel sounds
Practice each syllable separately

Spelling Benefits:

Easier to remember spelling
Helps with word recognition
Improves reading fluency

Definition of "possession"

Pronunciation: /pəˈzɛʃən/

Noun

Control or occupancy of something for which one does not necessarily have private property rights.
Something that is owned.

Example: "I would gladly give all of my worldly possessions just to be able to do that."
Ownership; taking, holding, keeping something as one's own.

Example: "I'm in possession of the car."
A territory under the rule of another country.

Example: "Réunion is the largest of France's overseas possessions."
The condition or affliction of being possessed by a demon or other supernatural entity.

Example: "Back then, people with psychiatric disorders were sometimes thought to be victims of demonic possession."
The condition of being under the control of strong emotion or madness.
Control of the ball; the opportunity to be on the offensive.

Example: "The scoreboard shows a little football symbol next to the name of the team that has possession."
A disposal of the ball during a game, i.e. a kick or a handball.
A syntactic relationship between two nouns or nominals that may be used to indicate ownership.

Example: "Some languages distinguish between a construction like 'my car', which shows alienable possession — the car could become someone else's — and one like 'my foot', which has inalienable possession — my foot will always be mine."

Verb

To invest with property.