How to pronounce "gage"

The brain is an amazing and complex organ.

And while many people are fascinated by the brain,

they can't really tell you that much

about the properties about how the brain works

because we don't teach neuroscience in schools.

And one of the reasons why is that the equipment

is so complex and so expensive

that it's really only done at major universities and large institutions.

And so in order to be able to access the brain,

you really need to dedicate your life

and spend six and a half years as a graduate student

just to become a neuroscientist to get access to these tools.

And that's a shame because one out of five of us,

that's 20 percent of the entire world, will have a neurological disorder.

And there are zero cures for these diseases.

And so it seems that what we should be doing

is reaching back earlier in the eduction process

and teaching students about neuroscience so that in the future,

they may be thinking about possibly becoming a brain scientist.

When I was a graduate student, my lab mate Tim Marzullo and myself,

decided that what if we took this complex equipment that we have

for studying the brain and made it simple enough and affordable enough

that anyone that you know, an amateur or a high school student,

could learn and actually participate in the discovery of neuroscience.

And so we did just that.

A few years ago, we started a company called Backyard Brains

and we make DIY neuroscience equipment and I brought some here tonight,

and I want to do some demonstrations.

You guys want to see some?

So I need a volunteer.

So right before -- what is your name? (Applause)

Sam Kelly: Sam.

Greg Gage: All right, Sam, I'm going to record from your brain.

Have you had this before?

SK: No.

GG: I need you to stick out your arm for science,

roll up your sleeve a bit,

So what I'm going to do, I'm putting electrodes on your arm,

and you're probably wondering,

I just said I'm going to record from your brain, what am I doing with your arm?

Well, you have about 80 billion neurons inside your brain right now.

They're sending electrical messages back and forth, and chemical messages.

But some of your neurons right here in your motor cortex

are going to send messages down when you move your arm like this.

They're going to go down across your corpus callosum,

down onto your spinal cord to your lower motor neuron

out to your muscles here,

and that electrical discharge is going to be picked up

by these electrodes right here

and we're going to be able to listen

to exactly what your brain is going to be doing.

So I'm going to turn this on for a second.

Have you ever heard what your brain sounds like?

SK: No.

GG: Let's try it out. So go ahead and squeeze your hand.

(Rumbling)

So what you're listening to,

so this is your motor units happening right here.

Let's take a look at it as well.

So I'm going to stand over here,

and I'm going to open up our app here.

So now I want you to squeeze.

(Rumbling)

So right here, these are the motor units that are happening

from her spinal cord out to her muscle right here,

and as she's doing it,

you're seeing the electrical activity that's happening here.

You can even click here and try to see one of them.

So keep doing it really hard.

So now we've paused

on one motor action potential that's happening right now inside of your brain.

Do you guys want to see some more?

(Applause)

That's interesting, but let's get it better.

I need one more volunteer.

What is your name, sir?

Miguel Goncalves: Miguel.

GG: Miguel, all right.

You're going to stand right here.

So when you're moving your arm like this,

your brain is sending a signal down to your muscles right here.

I want you to move your arm as well.

So your brain is going to send a signal down to your muscles.

And so it turns out that there is a nerve that's right here

that runs up here that innervates these three fingers,

and it's close enough to the skin that we might be able

to stimulate that so that what we can do

is copy your brain signals going out to your hand

and inject it into your hand,

so that your hand will move when your brain tells your hand to move.

So in a sense, she will take away your free will

and you will no longer have any control over this hand.

You with me?

So I just need to hook you up.

(Laughter)

So I'm going to find your ulnar nerve,

which is probably right around here.

You don't know what you're signing up for

when you come up.

So now I'm going to move away and we're going to plug it in

to our human-to-human interface over here.

Okay, so Sam, I want you to squeeze your hand again.

Do it again. Perfect.

So now I'm going to hook you up over here so that you get the --

It's going to feel a little bit weird at first,

this is going to feel like a -- (Laughter)

You know, when you lose your free will, and someone else becomes your agent,

it does feel a bit strange.

Now I want you to relax your hand.

Sam, you're with me?

So you're going to squeeze.

I'm not going to turn it on yet, so go ahead and give it a squeeze.

So now, are you ready, Miguel?

MG: Ready as I'll ever be.

GG: I've turned it on, so go ahead and turn your hand.

Do you feel that a little bit? MG: Nope.

GG: Okay, do it again? MG: A little bit.

GG: A little bit? (Laughter)

So relax.

So hit it again.

(Laughter)

Oh, perfect, perfect.

So relax, do it again.

All right, so right now,

your brain is controlling your arm and it's also controlling his arm,

so go ahead and just do it one more time.

All right, so it's perfect. (Laughter)

So now, what would happen if I took over my control of your hand?

And so, just relax your hand.

What happens?

Ah, nothing.

Why not?

Because the brain has to do it.

So you do it again.

All right, that's perfect.

Thank you guys for being such a good sport.

This is what's happening all across the world --

electrophysiology!

We're going to bring on the neuro-revolution.

Thank you.

(Applause)